![]() ![]() The cytoplasm is eosinophilic or stained with Orange G ( d). On imprint cytology, the cytoplasm of the atypical cells was large and the shape was irregularly round. C and D, An SLN with metastasis from a patient with squamous cervical cancer, the irregularly shaped and large nuclei indicate the presence of cancer cells in the frozen section ( c). Imaging from imprint cytology shows similar findings to the frozen section. A and B, frozen section ( a) and imprint cytology ( b) of a SLN without metastasis from a patient with endometrial cancer shows a normal population of lymphatic cells. H&E staining of frozen sections ( a, c and e) and Papanicolaou staining of imprint cytology ( b, d and f) from excised sentinel lymph nodes (SLNs) were evaluated. In these settings, the accuracy of the frozen section analysis and imprint cytology in the evaluation of SNB specimens was considered acceptable however, the sensitivity of the combined approach was higher in comparison to when a frozen section analysis or imprint cytology was performed alone.Ĭervical cancer Endometrial cancer Frozen section Imprint cytology Sentinel node biopsy. The negative predictive value of a frozen section analysis and imprint cytology was 98.7% and 98.5%, respectively. The specificity of a frozen section analysis and imprint cytology was 100%. The sensitivity of a frozen section analysis, imprint cytology and the combination of the two modalities was 76.5%, 72.6%, and 92.2%, respectively. Among 951 detected sentinel nodes, 51 nodes were found to be positive in the final pathological diagnosis. The diagnostic accuracy of intraoperative frozen section analyses and imprint cytology was compared to the final pathological diagnosis. The specimen was cut at 2-mm intervals into 5-μm-thick sections, which were subjected to hematoxylin and eosin staining. After performing imprint cytology, one half was used to create a frozen section. The sentinel node was cut in half, parallel to the longest axis, to obtain the maximum section area. Three hundred seventy-one patients with cervical and endometrial cancer received SNB with an intraoperative frozen section analysis and imprint cytology. The intraoperative diagnosis is important for guiding treatment decisions for patients with these conditions. Sentinel node biopsy (SNB) may be a decision-making tool for function preservation surgery, including radical trachelectomy and ovary preservation in the treatment of cervical and endometrial cancer. ![]()
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